Sustainable approaches in pharmaceutical discovery and development of sulfa drugs: A recommendation of green chromatography
Nguyen, Hai Anh (2020)
Nguyen, Hai Anh
2020
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Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:amk-202005046964
https://urn.fi/URN:NBN:fi:amk-202005046964
Tiivistelmä
As the environmental awareness is rising, the need for sustainable development emerges. This has given birth to Green Chemistry concept. Within this context, researchers are seeking for innovative approaches to reduce the negative impacts caused by hazardous chemicals on the environment. Being one of the industries that utilize and generate a vast amount of toxic organic substances, pharmaceuticals requires more attention into minimizing its environmental effects associated with the production and consumption of medicines. One of the most widely used drugs discussed in this paper is sulfonamides, also known as sulfa drugs. This class of drugs possesses a variety of biological activities ranging from antibiotics, anti-inflammatories to diuretics, hypoglycemics, carbon anhydrase inhibitors, and protease inhibitors. This is why sulfonamides are involved in many therapeutic medications, thus the environmental concerns relating to the preparation of this drug class needs to be considered. In fact, the production of sulfonamides exploits numerous toxic reagents, time, and energy, coupled with a remarkable generation of organic waste.
The discovery and development phases are considered as the most important process in the production of drugs. In this literature review thesis, green chromatography was suggested as a good technique to reduce the environmental problems associating with the analyses during pharmaceutical R&D phase yet ensuring the high-quality requirements of medicinal products. Gas chromatography with the use of hydrogen as a carrier gas in mobile phase was considered as the greenest technique in chromatographic analysis. Liquid chromatography is less green than gas chromatography, however, its versatility offers various approaches toward green chemistry goals. For example, choosing continuous operating instead of conventional batch mode can considerably reduce the solvent and time consumption. In other approaches, toxic organic solvent is replaced by green solvents such as supercritical carbon dioxide or superheated water.
The studied applications of green chromatographic techniques in this thesis involve, but are not limited to, the effective detection and separation of sulfonamides. Further development of these techniques into preparative scale for routine analysis of sulfa drug sis still required.
The discovery and development phases are considered as the most important process in the production of drugs. In this literature review thesis, green chromatography was suggested as a good technique to reduce the environmental problems associating with the analyses during pharmaceutical R&D phase yet ensuring the high-quality requirements of medicinal products. Gas chromatography with the use of hydrogen as a carrier gas in mobile phase was considered as the greenest technique in chromatographic analysis. Liquid chromatography is less green than gas chromatography, however, its versatility offers various approaches toward green chemistry goals. For example, choosing continuous operating instead of conventional batch mode can considerably reduce the solvent and time consumption. In other approaches, toxic organic solvent is replaced by green solvents such as supercritical carbon dioxide or superheated water.
The studied applications of green chromatographic techniques in this thesis involve, but are not limited to, the effective detection and separation of sulfonamides. Further development of these techniques into preparative scale for routine analysis of sulfa drug sis still required.