A novel fluorescent sensor for ultra-sensitive detection of Al3+ and its bioimaging application in living cells
Changling, Xu (2020)
Changling, Xu
2020
All rights reserved. This publication is copyrighted. You may download, display and print it for Your own personal use. Commercial use is prohibited.
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:amk-2021053112696
https://urn.fi/URN:NBN:fi:amk-2021053112696
Tiivistelmä
After the late 20th century, with the continuous development of industrialization worldwide, environmental pollution issues put a huge burden on society and living organisms. Many excessive metal ions have been found in humans and animals, as well as in the environment. It caused huge damage to functional organisms. For example, transitional metal ions Al3+, Cu2+, and other metal ions were considered a contributor to cancer. Thus, it is necessary to develop an efficient and convenient sensor for the rapid detection of metal ions. In this work, a novel fluorochrome based on thiophene Schiff base has been synthesized and investigated for ultrasensitive detection of Al3+ and its bioimaging application in living cells. with high selectivity and anti-interference over other metal ions, the TS displayed a very fast fluorescence-enhanced response towards Al3+ and with low detection limits TS (3.7 nM for Al3+ ) and wide pH response range TS (4.0–12.0) high stability TS (binding constant 1.16×104M-1). The sensing mechanism between Al3+ and TS was investigated, and the result shows that the chemical binding stoichiometric ratio of TS-Al3+ is 1:1. Importantly, experiments of TS-Al3+ have carried out in various environmental solutions and coated paper strips, and it worked well. More importantly, it can be used in living cells detection of Al3+, which granted its potential application in bioimaging.