Optimizing liquid chromatography analysis scheduling in pharmaceutical quality control : case study on schedule optimization to improve LC throughput in a QC laboratory

Abstract

This study, commissioned by a Finnish pharmaceutical company, investigates the efficiency of liquid chromatography (LC) analysis in raw material quality control. LC was identified as a major bottleneck due to complexity and resource constraints, affecting lead time and operational performance. The objective was to reduce lead time and improve equipment utilization while ensuring regulatory compliance. A mixed-method case study applying Lean principles and the DMAIC framework was conducted, including process mapping, cycle time analysis, and interview for LC analysts. Results revealed scheduling delays and underutilization of equipment. Implementing Lean tools and DMAIC steps reduced lead times and optimized resource allocation. Findings indicate that Lean and DMAIC methodologies can significantly enhance LC efficiency and provide a foundation for broader process optimization initiatives.