Ocular Manifestation in Marfan Syndrome : integrative literature review
Kemppainen, Leila (2025)
2025
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Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:amk-2025100825721
https://urn.fi/URN:NBN:fi:amk-2025100825721
Tiivistelmä
Background: Marfan Syndrome (MFS) is hereditary connective tissue disorder. The disease is characterized by specific features of the eye, cardiovascular system, and musculoskeletal system.
Purpose: The purpose of this thesis is to compile the visual symptoms and findings of a patient with Marfan Syndrome based on previous studies.
Methods: This integrative literature review was conducted using Pub-Med and EBSCO databases. The publication date of the texts was scheduled to be between 2015 and 2025. Finally, 14 studies were selected for this integrative literature review. All these studies were assessed using the Joanna Briggs Institute (JBI) Critical Appraisal Quality Assessment Checklists. Qualitative inductive content analysis was used to summarize the data.
Results: The results and findings of studies related to MFS and vision varied. In summary of all studies, it can be concluded that MFS affects vision, visual acuity and eye structures. High myopia, high astigmatism, reduced visual acuity and ectopia lentis were observed in most studies. Structural effects on the eyes included a flatter, thinner cornea, greater corneal astigmatism, shallow anterior chamber, low intraocular pressure, thicker crystalline lens and elongated zonules, and longer axial length of the eye.
Conclusions: The ocular symptoms of MFS vary, and eye findings may be suggestive of the condition. An optician may be the first to notice changes in the eyes that suggest MFS. The patient benefits from early diagnosis and treatment, which helps prevent eye problems and other systemic, life-threatening problems.
Purpose: The purpose of this thesis is to compile the visual symptoms and findings of a patient with Marfan Syndrome based on previous studies.
Methods: This integrative literature review was conducted using Pub-Med and EBSCO databases. The publication date of the texts was scheduled to be between 2015 and 2025. Finally, 14 studies were selected for this integrative literature review. All these studies were assessed using the Joanna Briggs Institute (JBI) Critical Appraisal Quality Assessment Checklists. Qualitative inductive content analysis was used to summarize the data.
Results: The results and findings of studies related to MFS and vision varied. In summary of all studies, it can be concluded that MFS affects vision, visual acuity and eye structures. High myopia, high astigmatism, reduced visual acuity and ectopia lentis were observed in most studies. Structural effects on the eyes included a flatter, thinner cornea, greater corneal astigmatism, shallow anterior chamber, low intraocular pressure, thicker crystalline lens and elongated zonules, and longer axial length of the eye.
Conclusions: The ocular symptoms of MFS vary, and eye findings may be suggestive of the condition. An optician may be the first to notice changes in the eyes that suggest MFS. The patient benefits from early diagnosis and treatment, which helps prevent eye problems and other systemic, life-threatening problems.