Safe Drinking Water Act Nitrite Method Feasibility Tests for the Gallery Analyzer
Oksanen, Viivi (2025)
2025
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Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:amk-2025113030930
https://urn.fi/URN:NBN:fi:amk-2025113030930
Tiivistelmä
In this thesis feasibility testing was conducted for nitrite determination by a Thermo Fisher Scientific™ Gallery™ Aqua Master discrete analyzer. These tests consisted of establishing a detection limit, reporting limit as well as initial precision and recovery for the method. In addition, a laboratory fortified matrix study was done with different matrices that are known to interfere with nitrite analysis. All the tests were conducted for the analyzer as well as a reference method, which was a manual turbidimetric photometric measurement.
The thesis was done for Thermo Fisher Scientific, as a part of a project aiming to get nitrite detection with Gallery approved as an official method for Environmental Protection Agency’s Safe Drinking Water Act. The experimental studies presented in this thesis were done to ensure that the created application is suitable for drinking water samples as well as to gather data for the alternative test procedure program, which is a procedure for evaluation and approval of new methods.
Every result was within the set specifications. For instance, the limit of detection was 0.33 µg N/L for Gallery and 1.5 µg N/L for the reference method. The reporting limit was 2.5 µg N/L for Gallery and 5 µg N/L for the reference method. The recovery percentages from the laboratory fortified matrix study were accurate, between 93-104 %, which indicates the great tolerance of different nitrite interferences with Gallery. The relative percentage difference between duplicate analyses was between 0.9–2.7 % with Gallery. The results obtained from the tests verified that the application is suitable for determining nitrite from drinking water samples.
The thesis was done for Thermo Fisher Scientific, as a part of a project aiming to get nitrite detection with Gallery approved as an official method for Environmental Protection Agency’s Safe Drinking Water Act. The experimental studies presented in this thesis were done to ensure that the created application is suitable for drinking water samples as well as to gather data for the alternative test procedure program, which is a procedure for evaluation and approval of new methods.
Every result was within the set specifications. For instance, the limit of detection was 0.33 µg N/L for Gallery and 1.5 µg N/L for the reference method. The reporting limit was 2.5 µg N/L for Gallery and 5 µg N/L for the reference method. The recovery percentages from the laboratory fortified matrix study were accurate, between 93-104 %, which indicates the great tolerance of different nitrite interferences with Gallery. The relative percentage difference between duplicate analyses was between 0.9–2.7 % with Gallery. The results obtained from the tests verified that the application is suitable for determining nitrite from drinking water samples.